23.2.1　FollicularatresiainnormalestrouscyclesOnday1afterovulation,therewereveryfewhealthyantralfolliclesintheovaries,andthenewcorporaluteawereobserved.Amassofdeadgranulosacellsseparatedfromthegranulosalayersandscatteredintheantrum.Furthermore,insomeatreti...[繼續(xù)閱讀]

    Inallfourratmodels,oneovaryofeachexperimentalanimalwereusedforhistologicalexaminationandtheotherovarywashomoginizedforRIAofcGMPlevelsandcGMP-PDEactivities.26.2.1　HistologicalexaminationOurmorphologicexaminationsoftheneonatalratovaryareidenticaltoourprevio...[繼續(xù)閱讀]

    Inthepresentstudy,wemakeacaseforcleavageofPARP-1beingstronglyimplicatedinporcinefolliculardevelopmentandatresiaoffetal,neonatalandadultporcineovaries.WedemonstratedthatPARP-1cleavagemightplayanimportantroleduringtheprocessoffolliculardevelopmentandatresia...[繼續(xù)閱讀]

    目前的研究已經(jīng)表明PI3K是PKB的上游信號分子,調(diào)控PKB信號通路的生理功能[8]。最近的研究也發(fā)現(xiàn)FoxO3a是PKB下游的一個重要信號分子,在卵巢功能調(diào)節(jié)中具有非常重要的調(diào)控作用。由此可見,PI3K/FoxO3a通路是調(diào)控哺乳動物卵巢卵泡發(fā)育的...[繼續(xù)閱讀]

    GnRH神經(jīng)元是HPG軸的主要調(diào)控者,腺垂體以脈沖的方式分泌GTH,包括FSH和LH。這兩種激素能夠作用于性腺,并促進性腺的發(fā)育和類固醇激素的分泌。性腺類固醇在大腦中的作用主要表現(xiàn)為GnRH的反饋調(diào)節(jié)與性行為的助長。激素和生長因子...[繼續(xù)閱讀]

    25.1.1　AnimalsandexperimentaldesignSprague-Dawleyrats(QinglongshanExperimentalAnimalSupplyCo.,Ltd.,Nanjing,P.R.China)wereusedinthepresentstudy.Theanimalsweremaintainedundera14-hlight(0500～1900h)/10-hdarkschedulewithfoodandwateravailableadlibitum.Theexperi...[繼續(xù)閱讀]

    [1]GARRIDOAM,GRIENDLINGKK.NADPHoxidasesandangiotensinⅡreceptorsignaling.MolCellEndocrinol,2009,302(2):148-158.[2]ZHANGC,HUJJ,XIAM,etal.Redoxsignalingvialipidraftclusteringinhomocysteine-inducedinjuryofpodocytes.BiochimBiophysActa,2010,1803(4):482-491.[3]Z...[繼續(xù)閱讀]

    Toourknowledge,thisstudyisthefirsttodemonstratethatthreeisoformsofNOSandsGCsubunitsinporcinefetalandneonatalovariesduringfollicularformationanddevelopment.Ourresultsclearlyshowcell-specificexpressionofthesethreeNOSisoformsandsGCsubunits.Inaddition,activit...[繼續(xù)閱讀]

    在哺乳動物中,生殖激素能夠調(diào)控卵巢功能,其中氣體信號分子NO信號通路在這個調(diào)節(jié)過程中起了非常重要的作用。目前的研究已經(jīng)表明NO是通過NOS生成的,而且NOS受到多種細胞因子和生殖激素的調(diào)控,如AngⅡ、FSH和hCG等。進一步研究還發(fā)...[繼續(xù)閱讀]

    [1]RICHARDSJS,FITZPATRICKSL,CLEMENSJW,etal.Ovariancelldifferentiation:acascadeofmultiplehormones,cellularsignals,andregulatedgenes.RecentProgHormRes,1995,50:223-254.[2]AHARONID,DANTESA,ORENMetal.cAMP-mediatedsignalsasdeterminantsforapoptosisinprimarygranu...[繼續(xù)閱讀]