Effects of Single Herbal Drugs on Adhesion and Migration of Melanocytes

摘要： <正> Objective:To find herbs with effects on adhesion and migration of melanocytes in vitro.Materials andMethods:Ethanol extracts from 14 herbs were tested.Normal human melanocytes were obtained fromneonatal foreskin,and the 48-well culture dish covered with fibronectin was used for the melanocyteadhesion assay.Motility was assessed by using the micropore filter method.Results:The extracts ofDanshen (丹參 Radix Salviae Mihiorrhizae),Tusizi (菟絲子 Semen Cuscutae) and Honghua (紅花 FlosCarthami) could enhance melanocyte adhesion to fibronectin,while Cijili (刺蒺藜 Fructus Tribuli) andHuangqi (黃芪 Radix Astragali) promote melanocyte migration in vitro.Buguzhi (補(bǔ)骨脂 FructusPsoraleae),Nü Zhen Zi (女貞子 Fructus Ligustri Lucidi) and Baizhi (白芷 Radix Angelicae Dahuricae)could promote both adhesion and migration of melanocytes.Conclusion:The above herbs may play arole through promoting adhesion and/or migration of melanocytes in the treatment of vitiligo. ... （共3頁(yè)）