脊髓小膠質(zhì)細(xì)胞中釋放ATP的SWELL1通道參與神經(jīng)病理性疼痛
中國疼痛醫(yī)學(xué)雜志
頁數(shù): 4 2023-09-15
摘要: 外周神經(jīng)損傷后,細(xì)胞外三磷酸腺苷(ATP)介導(dǎo)的嘌呤能信號對脊髓小膠質(zhì)細(xì)胞激活和神經(jīng)病理性疼痛至關(guān)重要。然而,ATP釋放的機(jī)制仍然知之甚少。該研究發(fā)現(xiàn)體積調(diào)控陰離子通道(volume-regulated anion channel, VRAC)是一個ATP釋放通道,在小膠質(zhì)細(xì)胞中被炎癥介質(zhì)鞘氨醇-1-磷酸(sphingosine-1-phosphate, S1P)激活。SWEL...